戊型病毒性肝炎研究进展

    陆敏，孙薇，潘德观，谭健，陈文珍

    广州机场出入境检验检疫局，广东广州 510470

    摘要：戊型病毒性肝炎（戊肝）是由戊肝病毒（HepatitisEVirus，HEV）引起的急性病毒性肝炎。HEV是一种单链、非包膜的RNA病毒，分为4个基因型，主要通过粪口途径传播，也可以通过输血传播和母婴传播。戊肝主要在发展中国家流行，但欧美等发达国家亦有散发病例。戊肝是一种人畜共患病。酶联免疫吸附实验（ELISA）是目前用于检测血清HEV抗体最常用的方法。HEVRNA检测可证实HEV感染。目前，HEV疫苗的研究主要集中在HEV基因工程疫苗的研制。2012年10月HEV疫苗上市。采用切断传播途径为主的综合性预防措施可控制该病的流行，接种疫苗也是预防戊型肝炎的重要措施。

    关键词：戊型病毒性肝炎；人畜共患病；血清学检测；基因工程；疫苗

    中图分类号：R512.6　文献标识码：B

    Research advances in Hepatitis E virus

    LU Min, SUN Wei, PAN De-guan, TIAN Jian, CHENWen-zhen

    Guangzhou Airport Entry-exit Inspection andQuarantine Bureau, Guangzhou, Guangdong 510470,China

    Abstract:   Objective   Hepatitis E (HE) isone kind of acute infectious disease caused by Hepatitis E Virus(HEV) which has four genotypes. HEV is one kind of sigle-line andnon-diolame RNA virus, which is transmitted in a faecal-oral route,metachysis and maternal-neonatal transmission. HE is occurspredominantly in developing countries, sometimes occurs in Europeand America. HE is one kind of zoonosis. ELISA is the main testmethod. And HEV RNA test is another effective method. At present,genetic engineering is the primary coverage in manufacture of HEVvaccine. In Oct. 2012, the first vaccine was developed, meanwhile,cutting off the route of transmission is another main measure ofHEV prevention.

    Key words:   Hepatitis E Virus; Zoonosis; ELISA;Genetic engineering; Vaccine

    《中国国境卫生检疫杂志》2013年10月刊