乙肝病毒前S1抗原检测在入境人员检测诊断中的应用价值

    陈宇飞1，云华2，王馨厚3

    1.内蒙古大学生命科学学院，内蒙古 呼和浩特010010；2.内蒙古国际旅行卫生保健中心；

    3.包头国际旅行卫生保健中心

    摘要：目的 评价乙肝病毒PreS1抗原在入境人员检测中的应用价值。方法将2008—2010年经我中心体检的362份入境乙肝病毒表面抗原（HBsAg）阳性的血清标本进行PreS1抗原检测，同时用PCR法进行乙型肝炎病毒基因（HBV-DNA）测定。结果PreS1总阳性率为41.16％，HBV-DNA阳性率为43.92％，乙肝病毒e抗原（HBeAg）阳性率为29.83％。PreS1总阳性率明显高于HBeAg阳性率。PreS1与HBV-DNA的总符合率为84.80％。结论PreSl抗原作为乙肝感染和复制的血清学指标敏感性高于HBeAg，对提示乙肝患者的病情发展和转归有重要临床意义。PreS1抗原可以作为一项新的乙肝病毒复制的指标在入境人员中进行筛查。

    关键词：入境人员；乙肝病毒；PreS1抗原；乙肝病毒e抗原

    中图分类号：R155.5　文献标识码：B

    Significance of detecting PreS1 antigen ofhepatitis B virus

    for entry personnel

    CHEN Yu-fei*, YUN Hua, WANG Xin-hou

    Life Sciences Department Of Inner MongoliaUniversity Huhot Innev Mongolia, 010010, China

    Abstract:   Objective  To evaluate the application value for detecting PreS1 antigen ofhepatitis B virus (HBV) in the detection and diagnosis among entrypersonnel.  Methods   PreS1 antigen detection amongthe 362 samples of HBV surface antigen (HBsAg)-positive serum weredetected from 2008 to 2010, and HBV-DNA by PCR wasdeterminated.  Results   Total positive rate ofPreS1 was 41.16%，the positive of rate HBV-DNA was 43.92％, thepositive rate of HBeAg was 29.83%. The total positive rate of PreS1was significantly higher than that of HBeAg. The coincidence rateof PreS1 and HBV-DNA was 84.80%.  Conclusion   Asserology index of HBV infection and replication, the PreS1 antigenis more sensitive than HBeAg. And it is important clinicalsignificance for indicating the progression and prognosis ofpatient with HBV. PreS1 antigen can be used as a new index HBVreplication for entry personnel screening.

    Key words:   Entry personnel；Hepatitis B Virus PreS1 antigen；HBeAg antigen

    《中国国境卫生检疫杂志》6月刊