2009年深圳口岸甲型H1N1流感疫情早期监测结果分析

    刘胜牙1，朱玉兰1，李政良1，甄胜西1，黄彤文1，胡孔新2，叶健忠1，董瑞玲1

    1.深圳国际旅行卫生保健中心，广东 深圳 518033；2.中国检验检疫科学研究院

    摘要：目的分析2009年深圳口岸甲型H1N1流感疫情暴发早期监测的结果，阐明甲型H1N1病毒的传入特征。方法对深圳罗湖、福田地铁、深圳湾、皇岗、蛇口、文锦渡、大铲湾、机场、沙头角9个国境口岸出入境人员实行流感监测，对监测到的流感样病例采集咽拭子标本，并进行流行病学调查。运用WHO推荐的甲型H1N1实时荧光RT-PCR技术检测流感样病例的咽拭子标本。结果2009年5月4日—2009年7月31日，深圳罗湖、福田地铁、深圳湾、皇岗、蛇口、文锦渡、大铲湾、机场、沙头角9个口岸监测到的流感样病例为2341份，其中，246份流感样病例的咽拭子标本中甲型流感病毒核酸检测阳性，检出率为10.51％；89份流感样病例的咽拭子标本中新型甲型H1N1流感病毒核酸检测阳性，检出率为3.80％。89份新型甲型H1N1流感病例中，男性54例，占60.67%，女性35例，占39.33%。早期病例年龄构成以50岁以下人群为主，其中，6~34岁人群最多，占总病例数的79.78％。89份甲型H1N1流感病例均为输入性病例。结论新型甲型H1N1流感疫情早期，深圳国境口岸监测到的输入性病例，从2009年5—7月，甲型流感病毒和新型甲型H1N1流感病例的检出率具有显著增加的趋势。

    关键词：甲型H1N1流感；亚型病毒；实时荧光RT-PCR技术；国境；口岸

    中图分类号：R511.7　文献标识码：B

    Analysis on monitoring results of influenza A（H1N1） in early stages of

    epidemic at Shenzhen ports

    LIU Sheng-ya*, ZHU Yu-lan, LI Zheng-liang,ZHEN Sheng-xi, HUANG Tong-wen,

    HU Kong-xin, YE Jian-zhong, DONG Rui-ling

    *Shenzhen International Travel Health CareCenter, Shenzhen, Guangdong 518033, China

    Abstract:   Objective  To analyze the monitoring results of influenza A (H1N1) in theearly stages of epidemic among entry-exit personnel at Shenzhenports,  and to explore the infectious characteristics ofinfluenza A (H1N1) virus.  Methods   The influenzasurveillance was implemented among entry-exit personnel from Luohu,Futian subway, Shenzhen wan, Huanggang, Shekou, Wengjindu,Dachanwan, Shenzhen Airport, and Shatoujiao Port. Throat swab frominfluenza-like illness patients were collected and epidemiologicalinvestigation was carried out. Throat swab were detected influenzaA (H1N1) by real-time RT-PCR that WHO recommended. Results   A total of 2 341 samples of throat swabs fromnine ports in Shenzhen from May 4 to July 31, 2009 were collected.A total of 246 cases were positive for influenza A virus nucleicacid detection and the positive rate was 10.51%. 89 specimens wereidentified as influenza A (H1N1) and the positive rate was 3.80%.Of these, 54 cases were male, accounting for 60.67%, 35 cases werefemale,  accounting for 39.33%. Conclusion   All ofinfluenza A (H1N1) cases were imported cases at Shenzhen ports. Thepositive rate of influenza A viruses and influenza A (H1N1) issignificantly increasing from May to July.

    Key words:   Influenza A (H1N1);Viruse; Real time RT-PCR; Frontier; Port

    《中国国境卫生检疫杂志》