肠出血性大肠杆菌O104：H4病原学及其检测方法研究进展

    刘丽珊1,2，黄吉城1，师永霞1

    1.广东出入境检验检疫局技术中心，广东 广州510700；2.中山大学公共卫生学院

   摘要：2011年5月以来，德国暴发了由肠出血性大肠杆菌O104：H4感染引起的疫情，世界多个国家相继报告有此类病例发生，这是首次报告由肠出血性大肠杆菌O104：H4感染引起疾病的暴发流行。截至2011年6月24日，已造成3920例感染和48例死亡[1]。该病患者以血水样腹泻、呕吐起病，部分病例并发溶血性尿毒综合征，导致多器官受损，甚至死亡。疫情发生后，世界各国相关学者立即开展其病原学特性研究，同时迅速研制出实验室检测方法和试剂，为该病的及时诊断、治疗和疫情控制发挥了很大作用。本文介绍了肠出血性大肠杆菌O104：H4病原学及其检测方法的研究进展。

    关键词：肠出血性大肠杆菌O104：H4；病原学；检测方法

    中图分类号：R183.4　文献标识码：B

    Research progress on etiology and detectionmethods of enterohaemorrhagic

    Escherichia coli (EHEC) O104:H4

    LIU Li-shan*, HUANG Ji-cheng, SHIYong-xia

    *Inspection and Quarantine Technical Center,Guangdong Entry-exit Inspection and Quarantine Bureau,

    Guangzhou， Guangdong 510700, China

    Abstract:   Since May 2011,Enterohaemorrhagic Escherichia coli(EHEC) O104:H4 has caused alarge outbreak of epidemic in Germany. Then some similar cases havebeen reported in other countries. It is the first outbreak causedby EHEC O104. By 24th June 2011, this outbreak has caused 3 920infections and 48 deaths.  The onset of symptoms of thedisease caused by EHEC are bloody diarrhoea and vomiting. Somecases may develop to haemolytic uraemic syndrome (HUS), which leadto multiple organ damage or even death. After the outbreak, thescientists in the world have studied the etiology characteristicsand established laboratory detection and reagents in a short time,which plays a large role in the preventing, treating andcontrolling the EHEC O104 infection. The etiology characteristicsof EHEC O104 and detection methods were introduced in thispaper.

    Key words:   EnterohaemorrhagicEscherichia coli O104:H4; Etiology; Detection Methods.

    《中国国境卫生检疫杂志》