乙肝疫苗接种无（低）应答原因及相应对策研究进展

    肖士海1，刘连庚2

    1.盐城出入境检验检疫局保健中心，江苏 盐城 224002；2.盐城市中医院

   摘要：本文总结了人体接种乙肝疫苗后，接种无（低）应答产生的原因，主要包括人体机体本身的因素，低水平乙肝（HBV）感染，接种部位、途径、接种次数，下淋巴细胞和细胞因子水平，遗传因素，乙肝的S基因变异，疾病因素，疫苗改造等；并就目前提高乙肝疫苗无（低）应答者免疫应答率的研究情况做一综述。

    关键词：乙肝疫苗；接种；应答；进展

    中图分类号： R512.6　文献标识码： B

    Research progress of non(low) -response causeto HB

    vaccine and corresponding countermeasures

    XIAO Shi-hai*,LIU Lian-geng

    *Yancheng Inspection QuarantineBureau，Yancheng， Jiangsu 224002, Chian

    Abstract:    This papersummarizes these no (low) responding causes， after the human bodyvaccination HepB, including human body itself factors, low levelhepatitis B virus (HBV) infection, vaccination site, approach,vaccination times, T lymphocytes and cytokines level, geneticfactors, hepatitis B S genetic variations, disease factors, thevaccine reform, etc ; and summarizing the research situation ofimproving immune response rates of the no (low) responders now.

    Key words:   HepatitisB；vaccine；Inoculation; Response; Progress