乙型肝炎病毒感染模式特征分析

    乙型肝炎病毒感染模式特征分析

    范 波1 王 飞1 田 茵1 陈建雄1 高莉敏2

    （1.北京国际旅行卫生保健中心，北京 100013；2.北京中医药大学管理学院，北京100029）

    摘要 〔目的〕分析2006—2008年在北京国际旅行卫生保健中心体检的全部出境人员和部分社会体检人员乙型肝炎病毒(HBV)感染情况及乙型肝炎血清标志物的感染模式特征。〔方法〕用酶联免疫吸附试验(ELISA)测定乙型肝炎病毒五项血清标志物。〔结果〕 在157627名体检人员中，乙型肝炎血清标志物有11种感染模式，一项或一项以上阳性者共18076例，感染率11.468%；其中31~40岁年龄段阳性者最多为4 746例，阳性率为3.011%；全部阴性139551例，占总数的88.532%。HBsAg阳性有4种组合模式共3 629人，检出率2.302%；HBsAb阳性有4种组合模式共4528例，检出率2.873%；HBeAg阳性有2种组合模式660例，检出率0.419%；HBeAb阳性有4种组合模式共5483例，检出率3.478%；HBcAb阳性有8种组合模式共14 533例，检出率9.220%；小三阳2342例，检出率为1.486%；单纯HBcAb阳性者7 112例，检出率为4.512%；单纯HBsAb阳性者3319例，检出率为2.106%。〔结论〕在北京国际旅行卫生保健中心体检人员中，乙肝感染率明显低于全国平均水平，乙肝血清标志物全部阴性者比例较高，提示加强这一群体的乙型肝炎免疫与检测工作十分重要。

    关键词 体检人员；乙型肝炎病毒；感染模式；特征分析

    〔中图分类号〕　R155.5　〔文献标识码〕　B

    Characteristic Analysis on Hepatitis B Virus(HBV) Infection Model   Fan Bo1, Wang Fei1, Tian Yin1,Chen Jianxiong1, Gao Limin2. (1. Beijing International TravelHealth Care Center, Beijing 100013, China; 2.Beijing University ofChinese Medicine, Beijing 100029,China.)

    [Abstract]   Objective  To analyze the characteristics of hepatitis B virus (HBV) infectionmode among exit personnel and some of the social medical staff from2006 to 2008.  Method   The serum markers ofhepatitis B virus was detected by Enzyme-linked immunosorbent assay(ELISA).  Result   In 157 627 samples, there were 11types of serum markers of HBV infection model. A total of 18 076cases were positive in one or more indicators, the infection ratewas 11.468%. In which, 139 551 persons were negative, accountingfor 88.532%. The largest number of positive group was 31~40 agegroup in which up to 4 746  the positiue rate was 3.011%. 3629 cases were positive of HBsAg with four kinds of modes, the ratewas 2.302%; 4 528 cases were positive of HBsAg with four kinds ofmodes, the rate was 2.873%; 660 cases were positive of  HBeAgwith two kinds of modes, the rate was 0.419%; 5 483 cases werepositive of HBeAb with four kinds of modes, the rate was 3.478%; 1453 cases were positive of HBcAb with eight kinds of modes, therate was 9.220%. The number of HBsAg(+) HBeAb(+) and HBcAb(+) were2 342 cases, the rate was 1.486%. The number of HBcAb(+) was 7 112,the rate was 4.512%; Only HBsAb(+) was 3 319, the rate was2.106%.  Conclusion  The rate of HBV infection issignificantly lower than the national average, all negative HBVserum markers had higher proportion, it is important to strengthenHBV immunization among exit groups.

    [Key words]   Medical staff; HBV;Infection mode; Characteristic analysis