乙肝病毒外膜大蛋白及其在出国人员健康体检中的应用价值

    胡 云 张培男 钱 进

    （1.镇江出入境检验检疫局，镇江 212008；2.昆山出入境检验检疫局，昆山215300；

    3.常州出入境检验检疫局，常州 213001）

    摘要 〔目的〕探讨乙肝病毒外膜大蛋白监测应用在健康体检中的价值及意义，为今后应用在出国劳务人员健康体检中探寻理论依据。〔方法〕通过对乙肝病毒外膜大蛋白的结构和功能的阐述，分析其检测技术的发展，探讨其在健康体检中的应用价值。〔结果〕乙肝病毒外膜大蛋白与DNA检测结果具有高度的正相关性，比现在使用的乙肝两对半指标更能反应慢性无症状乙肝病毒携带者体内病毒的复制状态。〔结论〕乙肝病毒外膜大蛋白检测可以作为判断肝内病毒继续复制或复制活跃程度的指标，在出国劳务人员健康体检中具有较高的应用价值，有助于体检单位评价体检者的健康状态。

    关键词 乙肝病毒；外膜大蛋白；酶联免疫吸附试验法；健康体检

    〔中图分类号〕　R51　〔文献标识码〕　B

    Hepatitis B virus Large Surface Protein andits Application Value of Health Examination among Labors GoingAbroad  Hu Yun1, Zhang Peinan2, Qian Jin3. (1.ZhenjiangEntry-exit Inspection and Quarantine Bureau, Zhenjiang 212008,China; 2.Kunshan Entry-exit Inspection and Quarantine Bureau,Kunshan 215300, China; 3.Changzhou Entry-exit Inspection andQuarantine Bureau, Changzhou 213001, China)

    [Abstract]  Objective  To researchthe value and significance of hepatitis B virus large surfaceprotein in the health examination, and to provide scientificevidences for labors going abroad in the future.  Methods   Description the structure and the function ofhepatitis B virus large surface protein were described and thedevelopment of detection technique was analyzed, the in the healthexamination for labors going abroad was studied application.Results   The hepatitis B virus large surface protein andhepatitis B virus DNA have a significant positive correlation. Itwas more better response of the viral replication status thandetection of HBV asymptomatic carriers. Conclusion   Thehepatitis B virus large surface protein can be used as indicatorsto determine virus active replication in the liver. It has a highapplication value in health examination, and it help doctorsevaluate the health status of those who undergo a medicalexamination.

    [Key words]   Hepatitis B virus;Large surface protein; Enzyme-linked immunosorbent assay (ELISA);Health examination